Rewriting the Autoimmune
Treatment Playbook

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Rewriting the Autoimmune Treatment Playbook

About Us

Esker Therapeutics is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Our experienced leadership team brings a proven track record in precision drug development of groundbreaking therapies.

Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer.

With a unique precision analytics platform and an unwavering commitment to advancing our understanding of immunologic diseases, Esker Therapeutics will rewrite the autoimmune treatment playbook by developing the right medicine for each patient.

Meet the Team


Leadership Team

Rewriting the Autoimmune Treatment Playbook

June Lee, M.D.

Chief Executive Officer, Co-founder, President

Mark Bradley

Chief Development Officer

David Zhang, Ph.D.

Senior Vice President, Chief Information Officer

Heike Paul

Director, Program Management

Board of Directors

Jim Tananbaum, M.D.

Founder and CEO, Foresite Capital

Michael Rome, Ph.D.

Managing Director, Foresite Capital

Vik Bajaj, Ph.D.

Managing Director, Foresite Capital & Co-founder and CEO, Foresite Labs

Zhengbin (Bing) Yao, Ph.D.

CEO and Co-founder, Viela Bio


Rewriting the Autoimmune Treatment Playbook

Why it Matters

Our goal is to eliminate suffering and fundamentally change the outcomes for patients living with  autoimmune diseases.

The broad impact of autoimmune disease in the U.S. requires a new approach and better options. We aim to do this by leveraging our precision analytics platform, powered by Foresite Labs, which comprises high-quality curated genetic, clinical and health records data. We then combine that information with the unmatched knowledge and expertise of our team, in order to inform which targets, pathways, indications, and patient subsets we pursue.


Cause of chronic illness
People in the US alone diagnosed with autoimmune disease
Average age at onset of 5 most common autoimmune diseases


Rewriting the Autoimmune Treatment Playbook

Our Approach


We aim to get the right medicine to each patient. Our leaders are experienced drug developers who are boldly committed to creating new knowledge and then following the science to take on the challenge of precision immunology.

We believe that our unique analytics platform with high-quality curated genetic, clinical and health records data will inform us on smarter targets, pathways, indications, and patient subsets to pursue.


Our Pipeline

We are building a pipeline of therapeutics based on genetically validated targets for application in the treatment of multiple autoimmune disease indications.


Our pipeline is led by ESK-001, a best-in-class TYK2 inhibitor currently in clinical development for psoriasis with multiple other indications soon to follow. TYK2 is a gene that encodes a member of the tyrosine kinase and, more specifically, the well-known Janus kinases (JAKs) protein families. It is a central node in the signaling pathways of cytokines known as key mediators of inflammation and autoimmune diseases. This highly validated target has the potential to effectively treat multiple autoimmune indications beyond psoriasis.

Beyond TYK2, we have several discovery assets comprised of rigorously validated targets for the potential treatment of autoimmune indications.


Authenticity is Our Core

Join Us

We are scientists, drug hunters and company builders – we’ve done this before – and we know that success comes from hard work, grit and staying true to our founding vision. We can’t create real, meaningful therapies for patients without being real with ourselves.

We invite you to join us on this epic journey. Find out how.

Join Us


What We’ve Been Up To

Latest News


Esker Therapeutics Launches to Transform the Treatment of Autoimmune Diseases

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